Institute of Bioinformatics Münster
Domain annotation
Detection and annotation of Protein domains with Interpro scan and Pfam scan
Summary
| Class | Number of Sequences |
|---|---|
| Pfam Domain | 9,620 |
| Interpro Domain | 9,160 |
| GO annotation | 6,020 |
| Total Proteins containing Domains | 9,620 |
Description
Protein domains are highly conserved functional units of proteins. Protein domains occur once or several times or none at all in proteins. Because of their conserved characteristic, they are used to study the evolutionary history of proteins. Changes like the addition or the deletion of domains in proteins give hints of evolutionary events. This could lead to changes in the function and/or the structure of the proteins.
Pfam
and Insterpro
are two big databases which contain protein domain data.
Pfam scan
and Interpro scan are search programs which detect protein domains in protein sequence data. The detected domains refer to existing proteins which are inside the protein predictions and to their function.
Results
Interproscan output file
Download Interpro scan annotation [Interpro scan output gff]
Classified Proteins with Interproscan prediction
- Figure 1: Distribution of protein domain findings in classified proteins.
Non-classified Proteins with Interproscan prediction
- Figure 2: Distribution of protein domain findings in Non-classified proteins.
2020-11-18 22:08