Uni Münster Med. Fakultaet
IoB
NEWS
2024-02
NewickTreeModifier: a simple web page to prune and modify Newick trees
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2023-08-28
"The complete sequence of a human Y chromosome” by T2T Consortium has been published by Nature
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2022-10-28
"The new uORFdb: integrating literature, sequence, and variation data in a central hub for uORF research” by Felix Manske, Lynn Ogoniak, Norbert Grundmann and Wojciech Makałowski has been published by Nucleic Acids Research.
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2022-07-08
"A Map of 3' DNA Transduction Variants Mediated by Non-LTR Retroelements on 3202 Human Genomes” by Reza Halabian and Wojciech Makałowski has been published by Biology.
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2022-06
"paPAML: An Improved Computational Tool to Explore Selection Pressure on Protein-Coding Sequences" by Lynn Ogoniak, Norbert Grundmann and others
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2022-05-14
"Mobilome of Apicomplexa Parasites" by Rodriguez and Makalowski has been published by Genes.
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2022-04-27
"Software evaluation for de novo detection of transposons" by Rodriguez and Makalowski has been published by Mobile DNA.
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2022-04-01
"From telomere to telomere: The transcriptional and epigenetic state of human repeat elements” by T2T consortium has been published by Science.
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2022-02-12
"Global research alliance in infectious disease: a collaborative effort to combat infectious diseases through dissemination of portable sequencing” by GRAID consortium that IoB is part of has been published by BMC Research Notes.
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2021-08-05
Congratulations to Reza and Matias on the excellent contribution on TE-driven DNA transductions in the human genome
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2021-05-29
"Somatic Functional Deletions of Upstream Open Reading Frame-Associated Initiation and Termination Codons in Human Cancer" was published by MDPI
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Dr. Ronaldo Schuch

Tradition Talk

Transcription factor (TF) binding pattern and arrangement within transcriptional start sites are crucial for the regulation of expression levels of various tumor related genes. A widely used method to analyze transcription factor binding sites (TFBSs) in vivo is the chromatin immunoprecipitation (ChIP). However, this method does not enable the individual investigation of neighboring TFBSs due to its unspecific DNA fragmentation technique. We established an improved ChIP technique which allows the detection of single TFBSs even in a complex of multiple adjacent binding motives of the same TF. We applied this new method to study the regulation of EGFR.

2011-06-28 15:10