O
WWU Münster UKM
IoB
NEWS
2018-08
"Bioinformatics v. 3" by Makalowski et al. has been published in eLS (Encyclopedia of Life Sciences).
View
2018-08-09
"Life cycle adapted upstream open reading frames (uORFs) in Trypanosoma congolense: A post-transcriptional approach to accurate gene regulation" by Fervers et al has been published by PLoS ONE
View
2018-07-23
"Mutational Intratumor Heterogeneity is a Complex and Early Event in the Development of Adult T-cell Leukemia/Lymphoma" by Farmanbar et al. has been published by Neoplasia
View
2018-05-29
"Nanopore sequencing of drug-resistance-associated genes in malaria parasites, Plasmodium falciparum" by Runtuwene at al. has been published by Scientific Reports
View
2018-05-25
Welcome Marten Kellner to our institute!
2018-05-07
Welcome Felix Manske to our institute!
2018-04-30
Ein- und Ausschalter der Gene: Muensters Wissenschaftler entdecken neue Form der Transkription zur Genregulation
View
2018-02-12
"Environmental adaptation of Acanthamoeba castellanii and Entamoeba histolytica at genome level as seen by comparative genomic analysis" Shabardina et al. has been published by Int. J. Biol. Sci.
View
2018-02-05
"Loss-of-function uORF mutations in human malignancies" by Schulz et al. has been published by Scientific Reports
View
2018-01-15
Welcome Jonas Bohn to our institute!
2018-01-04
"Transcriptional interference by small transcripts in proximal promoter regions" by Pande et al. has been published by Nucleic Acids Research.
View

Origin and evolution of U-12 dependent introns

Pre-mRNA splicing in eukaryotes is a fundamental step in gene expression and represents an important level at which the expression of protein-coding genes can be regulated . In higher eukaryotes, there are two classes of nuclear pre-mRNA introns. The most abundant class consists of U2-dependent introns (U2 introns), whereas the second rarer class (<0.4% of introns) consists of U12-dependent introns (U12 introns). U12 introns have been found in the nuclear genomes of vertebrates, plants, and insects. Introns belonging to these two distinct classes are spliced by two different spliceosomes: the major U2-type spliceosome and the less abundant U12-type spliceosome. Although the first U12 introns to be described had AT-AC terminal dinucleotides, the majority of U12-type introns contain GT-AG, and a small number contain other noncanonical terminal dinucleotides. We use statistical methods to discriminate the two classes of introns and investigate U12-introns evolutionaty distribution.

2012-11-19 14:06