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2018-02-12
"Environmental adaptation of Acanthamoeba castellanii and Entamoeba histolytica at genome level as seen by comparative genomic analysis" Shabardina et al. has been published by Int. J. Biol. Sci.
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2018-02-05
"Loss-of-function uORF mutations in human malignancies" by Schulz et al. has been published by Scientific Reports
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2018-01-15
Welcome Jonas Bohn to our institute!
2018-01-04
"Transcriptional interference by small transcripts in proximal promoter regions" by Pande et al. has been published by Nucleic Acids Research.
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2017-12-29
"The emerging picture of the mitochondrial protein import complexes of Amoebozoa supergroup" by Wojtkowska, Buczek et al. has been published by BMC Genomics.
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2017-09-05
Juan Manuel Galvez, welcome to our institute!
2017-09-05
Julian-Hendrik Matschke, welcome to our institute!
2017-07-11
Congratulations Philipp Fervers for for the successful defense of his doctoral thesis.
2017-07-24
Yukie Kashima, welcome to our institute!
2017-07-11
"Inferring clonal structure in HTLV-1-infected individuals: towards bridging the gap between analysis and visualization” by Farmanbar et al. has bee published by Human Genomics.
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2017-07-03
Welcome Reza Halabian, our new PhD student..
2017-06-27
"Sequencing and phasing cancer mutations in lung cancers using a long-read portable sequencer” by Suzuki et al. has bee published by DNA Research.
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2017-06-14
"Serotyping dengue virus with isothermal amplification and a portable sequencer.” by Yamagishi at al. has been published by Scientific Reports.
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Origin and evolution of U-12 dependent introns

Pre-mRNA splicing in eukaryotes is a fundamental step in gene expression and represents an important level at which the expression of protein-coding genes can be regulated . In higher eukaryotes, there are two classes of nuclear pre-mRNA introns. The most abundant class consists of U2-dependent introns (U2 introns), whereas the second rarer class (<0.4% of introns) consists of U12-dependent introns (U12 introns). U12 introns have been found in the nuclear genomes of vertebrates, plants, and insects. Introns belonging to these two distinct classes are spliced by two different spliceosomes: the major U2-type spliceosome and the less abundant U12-type spliceosome. Although the first U12 introns to be described had AT-AC terminal dinucleotides, the majority of U12-type introns contain GT-AG, and a small number contain other noncanonical terminal dinucleotides. We use statistical methods to discriminate the two classes of introns and investigate U12-introns evolutionaty distribution.

2012-11-19 14:06