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2019-01-24
"NanoPipe - a web server for nanopore MinION sequencing data analysis" by Shabardina et al. has been published by GigaScience.
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2018-12-29
"Transposable Elements Significantly Contributed to the Core Promoters in the Human Genome" by Kellner and Makalowski has been published by SCIENCE CHINA Life Sciences
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2018-12-14
A special seminar "Chironex indrasaksajiae (Cnidaria, Cubozoa), a new deadly box jellyfish from Thailand: From beachside to bench to clinical practice and to community" by Dr. Nuankanya Sathira from Mahidol University, Bangkok, Thailand.
2018-12-06
Defining a Characteristic Gene Expression Set Responsible for Cancer Stem Cell-Like Features in a Sub-Population of Ewing Sarcoma Cells CADO-ES1 - by Hotfilder, Korsching et al.
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2018-11-05
Welcome Philipp Meister to our institute!
2018-10-02
Welcome Matias Rodriguez to our institute!
2018-08
miR‐21‐5p, miR‐141‐3p, and miR‐205‐5p levels in urine - promising biomarkers for the identification of prostate and bladder cancer - by Ghorbanmehr Gharbi Korsching et al.
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2018-08
"Bioinformatics v. 3" by Makalowski et al. has been published in eLS (Encyclopedia of Life Sciences).
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2018-08-09
"Life cycle adapted upstream open reading frames (uORFs) in Trypanosoma congolense: A post-transcriptional approach to accurate gene regulation" by Fervers et al has been published by PLoS ONE
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Origin and evolution of U-12 dependent introns

Pre-mRNA splicing in eukaryotes is a fundamental step in gene expression and represents an important level at which the expression of protein-coding genes can be regulated . In higher eukaryotes, there are two classes of nuclear pre-mRNA introns. The most abundant class consists of U2-dependent introns (U2 introns), whereas the second rarer class (<0.4% of introns) consists of U12-dependent introns (U12 introns). U12 introns have been found in the nuclear genomes of vertebrates, plants, and insects. Introns belonging to these two distinct classes are spliced by two different spliceosomes: the major U2-type spliceosome and the less abundant U12-type spliceosome. Although the first U12 introns to be described had AT-AC terminal dinucleotides, the majority of U12-type introns contain GT-AG, and a small number contain other noncanonical terminal dinucleotides. We use statistical methods to discriminate the two classes of introns and investigate U12-introns evolutionaty distribution.

2018-11-15 11:50