O
WWU Münster UKM
IoB
NEWS
2018-05-29
"Nanopore sequencing of drug-resistance-associated genes in malaria parasites, Plasmodium falciparum" by Runtuwene at al. has been published by Scientific Reports
View
2018-05-25
Welcome Marten Kellner at our institute!
2018-05-07
Welcome Felix Manske at our institute!
2018-04-30
Ein- und Ausschalter der Gene: Muensters Wissenschaftler entdecken neue Form der Transkription zur Genregulation
View
2018-02-12
"Environmental adaptation of Acanthamoeba castellanii and Entamoeba histolytica at genome level as seen by comparative genomic analysis" Shabardina et al. has been published by Int. J. Biol. Sci.
View
2018-02-05
"Loss-of-function uORF mutations in human malignancies" by Schulz et al. has been published by Scientific Reports
View
2018-01-15
Welcome Jonas Bohn to our institute!
2018-01-04
"Transcriptional interference by small transcripts in proximal promoter regions" by Pande et al. has been published by Nucleic Acids Research.
View

Origin and evolution of mammalian overlapping genes

Overlapping genes in mammalian genomes are unexpected phenomena even though hundreds of pairs of protein coding overlapping genes have been reported so far. Overlapping genes can be divided into different categories based on genes orientation and parts being shared between overlapping genes. The biologic functions of natural antisense transcripts, their involvement in physiological processes and gene regulation in living organisms are not fully understood. Number of documented examples indicates that they may exert control at various levels of gene expression, such as transcription, mRNA processing, splicing, stability, transport, and translation. Similarly, evolutionary origin of such genes is not known, existing hypotheses can explain only selected cases of mammalian gene overlaps which could originate as result of rearrangements, overprinting, and/or adaption of signals in the neighboring gene locus.

2012-11-19 14:06