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2018-11-05
Welcome Philipp Meister to our institute!
2018-10-02
Welcome Matias Rodriguez to our institute!
2018-08
miR‐21‐5p, miR‐141‐3p, and miR‐205‐5p levels in urine - promising biomarkers for the identification of prostate and bladder cancer - by Ghorbanmehr Gharbi Korsching et al.
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2018-08
"Bioinformatics v. 3" by Makalowski et al. has been published in eLS (Encyclopedia of Life Sciences).
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2018-08-09
"Life cycle adapted upstream open reading frames (uORFs) in Trypanosoma congolense: A post-transcriptional approach to accurate gene regulation" by Fervers et al has been published by PLoS ONE
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2018-07-23
"Mutational Intratumor Heterogeneity is a Complex and Early Event in the Development of Adult T-cell Leukemia/Lymphoma" by Farmanbar et al. has been published by Neoplasia
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2018-05-29
"Nanopore sequencing of drug-resistance-associated genes in malaria parasites, Plasmodium falciparum" by Runtuwene at al. has been published by Scientific Reports
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2018-05-25
Welcome Marten Kellner to our institute!
2018-05-07
Welcome Felix Manske to our institute!

Origin and evolution of mammalian overlapping genes

Overlapping genes in mammalian genomes are unexpected phenomena even though hundreds of pairs of protein coding overlapping genes have been reported so far. Overlapping genes can be divided into different categories based on genes orientation and parts being shared between overlapping genes. The biologic functions of natural antisense transcripts, their involvement in physiological processes and gene regulation in living organisms are not fully understood. Number of documented examples indicates that they may exert control at various levels of gene expression, such as transcription, mRNA processing, splicing, stability, transport, and translation. Similarly, evolutionary origin of such genes is not known, existing hypotheses can explain only selected cases of mammalian gene overlaps which could originate as result of rearrangements, overprinting, and/or adaption of signals in the neighboring gene locus.

2012-11-19 14:06