WWU Münster UKM
IoB
NEWS
2020-03-18
"RAB5A and TRAPPC6B are novel targets for Shiga toxin 2a inactivation in kidney epithelial cells" by Kouzel at al. has been published by Scientific Reports.
Goto
2020-03-05
"Enhancer occlusion transcripts regulate the activity of human enhancer domains via transcriptional interference: a computational perspective" by Pande et al. has been published by Nucleic Acid Research
Goto
2020-01-21
Congratulations Felix Manske on getting the GBM-Masterpreis!
Goto
2019-12-18
"Emergence and evolution of ERM proteins and merlin in metazoans" by Shabardina et al. has been published by Genome Biology and Evolution
Goto
2019-12-16
"Loss of ADAMTS19 causes progressive non-syndromic heart valve disease" by Wünnemann et al. has been published by Nature Genetics
Goto
2019-11-04
Congratulations Matias for the "Best Poster" award at the X International Conference on Bioinformatics - Celebrating the 10th Anniversary of SoIBio and 10th Anniversary of the Master in Bioinformatics Uruguay.
2019-10-03
"Statins: Complex outcomes but increasingly helpful treatment options for patients" by Mohammadkhani, Korsching et al. has been published by European Journal of Pharmacology.
Goto
2019-10-01
Congratulations to Marten - another successful Master of Science.
2019-09-16
"An integrated genome-wide multi-omics analysis of gene expression dynamics in the preimplantation mouse embryo" by Israel, Makalowski et al. has been published by Scientific Reports.
Goto
Prof. Wojciech Makałowski
Biographical details
I joined the University of Muenster in January 2007. Prior to moving here, I worked at the Pennsylvania State University, USA (2001-2007), the National Center for Biotechnology Information (NCBI), NIH, USA (1994-2001), and the University of Montreal, Canada (1991-1993). My Ph.D. is from the Adam Mickiewicz University, Poznan, Poland (1991), and I also have a Master degree of Biology (1983) and a Master degree of Philosophy (1988) from the same university.
Contact
Telephone: +49 251 835 3006
Email: wojmak@uni-muenster.de
Research Interest
I am a molecular biologist with strong interest in evolution. My main research aims in understanding evolution at the genome level with special focus on transposable elements and their influence on a host genome. I am also interested in history and philosophy of science. In past I have been involved in large scale projects, e.g. sequencing and analysis of twelve drosophila genomes and H-inv project of annotating the human genome. Please email me if you are interested in joining my exciting research group or wish to discuss specific areas of my research program.
Current projects
  • Transposable Elements and gene transcription regulation.
  • TE-driven genomic transduction in health and disease.
  • Upstream open reading frames (uORFs) and cancer.
  • Transcriptomics of Amoebozoa with special focus on mitochondrial import apparatus.
  • Evolutionary genomics of apicomplexa parasites.
  • Bioinformatics software development with focus on nanopore sequencing.
Collaborations
Recent grants
2011 Genome Sciences – Evolutionary And Functional Perspective. FP7-People-2009-IRSES Project ‘‘EVOLGEN’’ No. 247633.
Publication Summary (February 2020)
  • 154 published papers
  • 7,562 total citations (according to google scholar)
  • H-index = 39
Selected recent publications
  • Shabardina V, Kashima Y, Suzuki Y, Makalowski W. (2020) Emergence and Evolution of ERM Proteins and Merlin in Metazoans. Genome Biol Evol. 12(1):3710-3724. doi: 10.1093/gbe/evz265.
  • Wünnemann F, Ta-Shma A, Preuss C, Leclerc S, van Vliet PP, Oneglia A, Thibeault M, Nordquist E, Lincoln J, Scharfenberg F, Becker-Pauly C, Hofmann P, Hoff K, Audain E, Kramer HH, Makalowski W, Nir A, Gerety SS, Hurles M, Comes J, Fournier A, Osinska H, Robins J, Pucéat M; MIBAVA Leducq Consortium principal investigators, Elpeleg O, Hitz MP, Andelfinger G. (2020) Loss of ADAMTS19 causes progressive non-syndromic heart valve disease. Nat Genet. 52(1):40-47. doi: 10.1038/s41588-019-0536-2. Epub 2019 Dec 16.
  • Makałowski W, Shabardina V. (2020) Bioinformatics of nanopore sequencing. J Hum Genet. 65(1):61-67. doi: 10.1038/s10038-019-0659-4. Epub 2019 Aug 26.
  • Israel S, Ernst M, Psathaki OE, Drexler HCA, Casser E, Suzuki Y, Makalowski W, Boiani M, Fuellen G, Taher L. (2019) An integrated genome-wide multi-omics analysis of gene expression dynamics in the preimplantation mouse embryo. Sci Rep. 16;9(1):13356. doi: 10.1038/s41598-019-49817-3.
  • Makałowski W, Gotea V, Pande A, Makałowska I. (2019) Transposable Elements: Classification, Identification, and Their Use As a Tool For Comparative Genomics. Methods Mol Biol. 2019;1910:177-207. doi: 10.1007/978-1-4939-9074-0_6.
  • Shabardina V, Kischka T, Manske F, Grundmann N, Frith MC, Suzuki Y, Makalowski W (2019) NanoPipe - a web server for nanopore MinION sequencing data analysis. GigaScience, giy169, doi: 10.1093/gigascience/giy169
  • Kellner M, Makalowski W (2018) Transposable Elements Significantly Contributed to the Core Promoters in the Human Genome. SCIENCE CHINA Life Sciences. doi: 10.1007/s11427-018-9449-0
  • Makalowski W, Shabardina V, Makalowska I (2018) Bioinformatics. eLS, John Wiley & Sons, Ltd (Ed). doi:10.1002/9780470015902.a0005247.pub3
  • Pande A, Brosius J, Makalowska I, Makalowski W, Raabe CA. (2018) Transcriptional interference by small transcripts in proximal promoter regions. Nucleic Acids Res. 2018 Feb 16;46(3):1069-1088.
  • Shabardina V, Kischka T, Kmita H, Suzuki Y, Makalowski W. (2018) Environmental adaptation of Acanthamoeba castellanii and Entamoeba histolytica at genome level as seen by comparative genomic analysis. Int J Biol Sci 14(3):306-320. doi:10.7150/ijbs.23869
  • Suzuki A, Suzuki M, Mizushima-Sugano J, Frith MC, Makalowski W, Kohl T, Sugano S, Tsichihara K, Suzuki Y (2017) Sequencing and phasing cancer mutations in lung cancers using a long-read portable sequencer. DNA Research. 24(6):585-596. DOI: 10.1093/dnares/dsx027.
  • Farmanbar A, Firouzi S, Makalowski W, Iwanaga M, Uchimaru K, Utsunomiya A, Watanabe T, Nakai K (2017) Inferring clonal structure in HTLV-1-infected individuals: towards bridging the gap between analysis and visualization. Hum Genomics. 11(1):15. DOI: 10.1186/s40246-017-0112-8.
  • Makalowski W, Kischka T, Makalowska I (2017) Contribution of Transposable Elements to Human Proteins. eLS. John Wiley & Sons, Ltd: Chichester. DOI: 10.1002/9780470015902.a0020793.pub2
A complete list of publications (most are full-text downloadable) can be found here
2020-02-11 15:59